Cannabidiol( CBD ), a non-psychoactive
component of the marijuana plant, has generated significant interest among
scientists and physicians in recent years, but the way in which
the CBD exerts its therapeutic impact at a molecular level remains a
research topic for scientists. Cannabidiol is a pleiotropic drug in the
sense that it produces many effects through multiple molecular pathways.
Although CBDhas
little binding affinity for either of the two cannabinoid receptors
( CB1and CB2 ), CBD activates several non-cannabinoid
receptors and ion channels. It also acts through several
receptor-independent channels-for example, by delaying the "reuptake"
of endogenous neurotransmitters (such as anandamide and adenosine) and by
increasing or inhibiting the binding action of certain receptors coupled to
type G proteins.
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